Size and charge selective permeability defects induced in glomerular basement membrane by a polycation
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چکیده
منابع مشابه
The glomerular basement membrane charge-selectivity barrier: an oversimplified concept?
The precise nature and role of a charge-selectivity barrier, existing at the level of the glomerular capillary wall has been the subject of continuing controversy since it was first postulated over 30 years ago. Recent studies suggest that some earlier observations may have been overinterpreted and that the conclusions reached should be re-examined. The concept of a charge-selectivity barrier a...
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The noncollagenous domain hexamer of collagen IV from bovine glomerular basement membrane was further investigated to determine the types of collagen chain from which subunits M2*b and M3 are derived. M2*b was shown to be a shorter form, containing 9 fewer residues, of M2*a which was previously established as the noncollagenous domain of a third chain, a3, of collagen IV (Saus, J., Wieslander, ...
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Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a component of the renal filtration barrier--the glomerular basement membrane (GBM)--can disassemble cationic cyclodextrin-containing polymer (CDP)-based siRNA nanoparticles and, thereb...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1984
ISSN: 0085-2538
DOI: 10.1038/ki.1984.2